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Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice

Highlights
•Energy intake was linked only to dietary fat levels and not protein or sucrose
•Adiposity increased with increasing fat content to 60% but thereafter declined
•Hypothalamic hunger pathways were unresponsive to dietary protein content
•Dopamine, opioid, and serotonin pathways were all stimulated by fat intake

https://www.cell.com/action/showImagesData?pii=S1550-4131%2818%2930392-9

Dr. William Davis says it shouldn't be long term, as it creates a stress response.
I wonder if he's had some new 'ah-has' along the way. 

Researchers examined the blood of 713 subjects for trends and prevalence of antibodies and found some interesting things:

https://vibrantwellnessblog.wordpress.com/2018/06/11/connective-tissue-disorders-and-wheat-a-new-connection/

Just had a second set of blood work come through on this diet.


I reduced fasting blood glucose by 8%  ( 99 to  91)
I reduced my triglycerides by 36%
I increased by HDL my 16%

This may surprise you.

Results from this meta-analysis of eighteen randomised controlled trials show no significant effect of 100 % fruit juice on fasting blood glucose, fasting blood insulin, insulin resistance as evaluated by HOMA-IR or HbA1c.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736636/

Remember that test I did last month where those cooked/cooled potatoes and rice still kept me in ketosis?   Turns out it actually improves insulin sensitivity, independent of the gut microbiota and could "involve alterations in the bile acid cycle and adipose tissue immune modulation."
   

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294823

Barbara -  It's an eye opener for sure.   I've been going low carb for a long time (since starting this forum), and have not been successful in losing any weight at all.  It's had me stumped for a long time.  I exercise every day as well. I just did a fasting insulin test (which I ordered on my own from Direct Labs) and found out that I'm insulin resistant.  Talk about an eye-opener.  My A1C is 5.5, so it never occurred to me that I could be insulin resistant.   And with insulin resistance, your body keeps producing more insulin, and making you more insulin resistant, which makes it impossible to lose weight.  My insulin is so high that I'm on my way to diabetes ... and that's on a low carb diet with normal blood sugar!  Who would have thunk!


My plan going forward:
- Increase my soluble fiber intake - especially chia  (In fact, I'll probably do organic steel cut oats with chia, cinnamon and almonds for breakfast - heresy! ) lol
- Eat more dark chocolate
- Increase my cinnamon intake
- Increase my green tea intake
- Increase my intermittent fasting times (I usually do a 12-14 hour fast everyday ... but I think I need to increase that.)
- Increase the apple cider vinegar intake
- Remove cheese, as casein and whey spike insulin.
- Increase veggies and eat 2 servings of fruit per day
- Decrease meat consumption
- Reduce egg consumption
- Reduce saturated fat

Trouble with weight loss?  Perhaps you are targeting the wrong pathways.  This article is worth reading:


https://idmprogram.com/why-cant-i-lose-weight-htlw-12/

Barb-  I think that great that you do IF.


Here's an article that I thought did a great job of explaining cortisol's impact on insulin. 
https://idmprogram.com/closer-look-cortisol-hormonal-obesity-xxxx/


I think I'm up there on the cortisol too.

Here's something surprising: "High protein, virtually no-carb foods like meat and eggs, while low on the glycemic index, measured high on the insulin index. In other words, while the meat and eggs didn’t cause a spike in blood sugar the way most carbohydrates do, they did result in an unexpectedly significant rise in insulin. "


https://www.marksdailyapple.com/insulin-index/

Bile is reabsorbed if it's not bound to fiber.  If it's bound to fiber, it comes out in the feces and the liver makes fresh bile.   When bound, it takes cholesterol and waste with it.  Bile salts are made of cholesterol.  Cholesterol as you know is a precursor to many sex hormones such as estrogen and testosterone.  (Which is why statin use leads to viagra use.)


Here's the role of bile:  http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/bile.html


This is how bile binds to fiber:  http://www1.lsbu.ac.uk/water/dietary_fiber.html#bile


On fiber lowering cholesterol:  https://www.ncbi.nlm.nih.gov/pubmed/21776465


On fiber lowering estrogen:  https://www.ncbi.nlm.nih.gov/pubmed/8039147


Binding capacity of fiber on certain toxins:  https://www.sciencedirect.com/science/article/pii/S0304389410014159

Just learned something new today.   The Inuit, who live on a high fat diet, have a gene that stops them from going into ketosis.

The ketone test strips... as mentioned earlier.  This shows excess ketone bodies (acetoacetate) excreted via urine.  It's pretty accurate if it has a ketone reading.   As you become more keto-adapted however, you excrete less in the urine, and a blood test might be better, as it shows different ketone bodies.  But for now, it's showing I'm in ketosis.   

Also, with regards to your earlier comment about exogenous ketones, I'm in agreement that supplementing with ketones doesn't necessarily improve health.

Betahydroxybuterate in the blood does not indicate ketosis.

I did a urine test, which I believe measures acetoacetate.

I decided to try cooked, cooled, and reheated potatoes, as well as cooked, cooled and frozen rice with an otherwise ketogenic diet.


The potato serving each day was around 4 ounces.  I loaded them up with butter, sour cream and cheese.  Yum!


Potatoes were cooled overnight.  The rice was cooked, frozen and reheated.  (So they both had plenty of time to turn to resistant starch.)





After 5 days of doing this, my ketone test strips say I'm in ketosis.

Goldman Sachs asks in biotech research report: 'Is curing patients a sustainable business model?'

https://www.cnbc.com/2018/04/11/goldman-asks-is-curing-patients-a-sustainable-business-model.html

"The potential to deliver 'one shot cures' is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies," analyst Salveen Richter wrote in the note to clients Tuesday. "While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow."

Just proves sick people are profitable.   

Yum!  Those do look good!

Good points Bob and Barbara. 

Think about enforcing and managing something like this.  And what department would make those decisions?   

My gut says nothing will change.

I corrected the nom nom link in your post Barbara.   

And great to hear from you BarbinNC.  It's been a long time.  Hope all is well in your world.

Thanks for sharing Barb!

Well... you can always eat a lot of butter. 

lol.  They actually have that?

Interesting article:

"Tryptophan-depletion studies have been done for years, as a way to study the relationship between low serotonin and depression.  Often a tryptophan-deficient amino acid mixture is used for this purpose. More recently, collagen and gelatin are being used."

https://www.everywomanover29.com/blog/collagen-gelatin-lower-serotonin-increase-anxiety-depression/

Wow!  Thanks Barbara!  You are such a wealth of information!

https://mobile.nytimes.com/2017/12/23/health/obesity-malaysia-nestle.html

In Asia’s Fattest Country, Nutritionists Take Money From Food Giants
When the food industry funds nutritionists, critics say it subverts science to preserve its market.

"KUALA LUMPUR, Malaysia — Over the past three decades this increasingly prosperous nation has become the fattest country in Asia, with nearly half the adult population now overweight or obese." [...] 

"Among the published articles was one that concluded that children who drank malted breakfast beverages — a category dominated in Malaysia by Milo, a sugary powder drink made by Nestlé — were more likely to be physically active and spend less time in front of a computer or television."

[...]

"According to their annual accounting reports, the nutrition society has received hundreds of thousands of dollars from industry, including at least $188,000 from Nestlé and Cereal Partners Worldwide — a joint venture between Nestlé and General Mills — for the breakfast study. It has also received at least $44,000 directly from Nestlé for other projects and collaborations; about $11,000 from the dairy industry; $10,000 from the artificial sweetener company Ajinomoto, which makes aspartame; and at least $40,000 from Philips Avent, the baby and consumer products company, for projects related to infant and maternal nutrition."